Animal copy research have not been carried out While using the drug mixture-promethazine and codeine. It's not at all recognized whether this drug blend can result in fetal damage when administered to a pregnant lady or can have an impact on reproduction capability.
A possibly deadly symptom advanced in some cases often called Neuroleptic Malignant Syndrome (NMS) has become documented in association with promethazine HCl alone or together with antipsychotic medicines.
clients that are allergic to promethazine, any from the components in promethazine, or to other phenothiazines
Impaired secretion from sweat glands next harmful doses of medication with anticholinergic Unwanted effects could predispose to hyperthermia.
Stay away from the use of Promethazine HCl and Codeine Phosphate Oral Option in adolescents twelve to eighteen a long time of age who have other chance variables that will maximize their sensitivity to your respiratory depressant results of codeine.
The mix of promethazine hydrochloride and codeine phosphate needs to be applied with warning in pediatric affected individual 6 several years and more mature (see WARNINGS – Use in Pediatric People).
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Option should not be increased if cough fails to respond; an unresponsive cough ought to be reevaluated in 5 times or faster for achievable underlying pathology, including international overall body or reduce respiratory tract disorder [see Dosage and Administration (2.three)].
Excessively massive dosages of antihistamines, including Promethazine HCl Oral Solution, in pediatric patients may well cause unexpected death (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric sufferers. In pediatric individuals who're acutely ill connected to dehydration, You can find a heightened susceptibility to dystonias with using Promethazine HCl.
Warning must be exercised when administering Promethazine to pediatric people two a long time of age and more mature. It is suggested that the bottom powerful dose of Promethazine be Utilized in pediatric sufferers 2 decades of age and older and concomitant administration of other medication with respiratory depressant consequences be avoided.
Promethazine HCl Oral Remedy really should be employed in the course of pregnancy only if the possible reward justifies the potential threat towards the fetus.
INDICATIONS AND USAGE Promethazine HCl and Codeine Phosphate Oral Alternative is a mix of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the short-term relief of cough and upper respiratory indicators connected with allergy or perhaps the popular cold in sufferers 18 yrs of age and older. (1)
Respiratory complications (respiratory depression)that may lead to death and opioid withdrawal can take place if you start having or prevent taking other medicines though having Promethazine website Hydrochloride and Codeine Phosphate Oral Solution, which includes:
Excessively large dosages of antihistamines, together with Promethazine HCl Oral Remedy, in pediatric patients may trigger unexpected Loss of life (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of Promethazine HCl Oral Remedy in pediatric patients. In pediatric clients who are acutely ill associated with dehydration, You can find a heightened susceptibility to dystonias with using promethazine HCl.
Promethazine HCl Oral Option might be applied by itself or as an adjunct to narcotic analgesics for the duration of labor (see DOSAGE AND ADMINISTRATION). Confined information propose that usage of Promethazine HCl Oral Solution in the course of labor and shipping doesn't have an considerable impact on the period of labor or supply and doesn't raise the chance of need to have for intervention during the new child.